Repair Mechanism of Osteochondral Defect Promoted by Bioengineered Chondrocyte Sheet
نویسندگان
چکیده
منابع مشابه
Use of allogeneic scaffold-free chondrocyte pellet in repair of osteochondral defect in a rabbit model.
Cell-based therapies are currently being used in treating osteochondral defect (OCD), but technical advances are needed to tackle the problems of scaffold and grafting technique. This study aimed to test the potential of allogeneic scaffold-free bioengineered chondrocyte pellet (BCP) in treating OCD. BCP was fabricated from rabbit costal cartilage and implanted into 3 mm × 3 mm OCD in medial fe...
متن کاملBiomimetic biphasic scaffolds for osteochondral defect repair
The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structure...
متن کاملPorous tantalum biocomposites for osteochondral defect repair
OBJECTIVES We sought to determine if a durable bilayer implant composed of trabecular metal with autologous periosteum on top would be suitable to reconstitute large osteochondral defects. This design would allow for secure implant fixation, subsequent integration and remodeling. MATERIALS AND METHODS Adult sheep were randomly assigned to one of three groups (n = 8/group): 1. trabecular metal...
متن کاملRepair of porcine articular cartilage defect with autologous chondrocyte transplantation.
Articular cartilage is known to have poor healing capacity after injury. Autologous chondral grafting remains the mainstay to treat well-defined, full-thickness, symptomatic cartilage defects. We demonstrated the utilization of gelatin microbeads to deliver autologous chondrocytes for in vivo cartilage generation. Chondrocytes were harvested from the left forelimbs of 12 Lee-Sung pigs. The cell...
متن کاملMucosal defect repair with a polyglycolic acid sheet.
OBJECTIVE Early-stage oral or oropharyngeal carcinomas are often treated with surgical resection. Resulting wounds that are too large for primary closure can be covered with skin grafts or patches made from various biomaterials. Recently, polyglycolic acid sheets have been used for this purpose. METHODS We treated six patients with large wounds resulting from the resection of oral or orophary...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2015
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2014.0310